Chukwuemeka P Azubuike 
,
Uloma N Ubani-Ukoma,
Abiola R Afolabi,
Ibilola M Cardoso-Daodu
For correspondence:- Chukwuemeka Azubuike Email: cazubuike@unilag.edu.ng Tel:+2348033618556
Accepted: 17 February 2020 Published: 31 March 2020
Citation: Azubuike CP, Ubani-Ukoma UN, Afolabi AR, Cardoso-Daodu IM. Evaluation of super-disintegrant potential of acid-modified starch derived from Borassus aethiopum (Aracaceae) shoot in paracetamol tablet formulations. Trop J Pharm Res 2020; 19(3):459-465 doi: 10.4314/tjpr.v19i3.1
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the super-disintegrant potentials of acid modified Borassus aethiopum starch (AMS) in comparison with native starch (NS) and commercial disintegrant sodium starch glycolate (SSG).
Methods: Compatibility of AMS with paracetamol powder was evaluated using Fourier transform infra-red (FTIR) spectrophotometry. Seven batches of paracetamol granules and tablets were prepared by wet granulation. AMS and NS were employed as disintegrants at concentrations of 2.43, 4.86 and 9.72 %w/w, respectively while 4.86 %w/w SSG was used as standard disintegrant. All the batches of the granules were compressed under the same compression settings. The properties of the granules as well as those of the tablets were assessed.
Results: AMS was compatible with paracetamol powder as no noticeable interaction was observed in FTIR study. The paracetamol tablets formulated using AMS as disintegrant demonstrated satisfactory friability, weight uniformity, hardness, and superior disintegration characteristics to the formulations containing NS and SSG as disintegrant. Even at a lower concentration (2.43 %w/w), AMS possessed better disintegrant property than NS and SSG. AMS and NS had dimensionless disintegrant quantity of 1.447 and 0.005, respectively. As expected, increase in AMS concentration showed a decrease in disintegration time.
Conclusion: AMS could be a potential low-cost super-disintegrant in formulation of paracetamol tablets.
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